its best to use both twice a day after cleansing your face, morning and night. also you can wear makeup after you apply it, but let it dry first. you should use both of them together, apply pore minimizer first, let it dry, then apply intensive pore treatment, let it dry, apply moisturizer, then makeup. i don't think this makes a good primer however.
husband has red skin and it quiets skin. I use twice a day before make up if going out or other treatments. Do not over do pore minimizer as waste of product and will pill, less is more! I think Pore Minimizer makes a great primer. Do allow time for product to sink in before next step.
I have used both products for about 3 weeks and am amazed with the great results. I use both morning and night, starting with minimizer (be sure to shake 1st!), letting product dry then following with treatment, letting it dry a bit before foundation application. The treatment is creamy and serves as a sort of primer. I would not use it everywhere unless you have extremely acne prone or oily skin. My skin is dry (with rosacea), so I confine application to nose & chin where clogged, enlarged pores are. I have NEVER been more pleased with ANY product purchased from Sephora!