YES, if you lube up your face really good with a moisturizing face soap first. DON'T use it on face skin that is JUST wet, definitely add something slippery first like soap -- and go EASY at first until you find out how much "scrubbing pressure" your face skin likes. That being said, my skin is delicate & sensitive & I love LIGHTLY scrubbing my face in the shower with this mitt. It's VERY exfoliating -- great for using before self-tanner, for example. DEFINITELY I do my face first (before the rest of my body) & then I machine-wash(and air dry) the mitt to get ready for the next time. The mitt launders beautifully and when it's squeaky clean, your face skin may just love it!
I would not use the coarse side on your face, much too abrasive. But you can get more gentle textured gloves that you can use with a light touch on your face. Just look in the spa/bath section of most drugstores, etc.