My understanding of many Asian skin care regimens is that the cream formulas are to be used last, use the thinner more watery products first. For instance, I have the SK-II Stempower Cream, SK-II Essence, and the SK-II Facial Lift Emulsion on my vanity. If I were layering the products I believe it would be Essence, Facial Lift, then Stempower Cream. If I had a serum it would be applied after the Essence... if I had an eye cream it would be applied right before the Stempower Cream. One more tip I read is to give your skin about 5 minutes to absorb each application. The SK-II products are beneficial even if you only use ONE of them, (I love this line)... so basically I found that I don't really 'have' to layer, which means I will get a lot more life out of my purchases. Hope this helps, good luck :)

From what I understand, this (my jar says Stem Power but I got it from Japan) currently replaced the Skin Signature line. I think they added ginseng root extract or something like that :) I just started using this a month ago so I had not tried the original but I can say with certainty that this works wonders... hope that helps :)