In my opinion the main difference is really the consistency. For instance, the essence is very thin and watery so it absorbs straight away, the facial lift emulsion is a light lotion consistency that you can feel on your face for a little while after application, the moisturizing cream penetrates deeper for more repair so it's creamier and concentrated, I use this one overnight... I think it just depends on how much age correcting power you feel you need. Any product in this line is surely going to be beneficial, you can't really go wrong.... this stuff is amazing. Personally, I found sample sizes and tested until I was satisfied with one main choice (which for me was the Essential Power Moisturizer )... best of luck & hope this helped :)