I exfoliate with my clarisonic daily and use this masque about every other day and they definitely work well together. Not too harsh at all.
I've used it in conjunction with Philosophy retinol products and I don't think there is a problem with layering. Evening routine: shower and use clarisonic w/ enzymatic cleanser, tea tree toner, retinol pad (but I admit, I don't use every night), acne treatment with B vitamins, eye cream, moisturizer (retinol or not), sulfur mask where I need it only. I would think you might want it to be your last step? It is a little drying, so if I put it on last I can control where it goes.
answered 2 years, 6 months ago